Investigating how inflammation affects heart function and arrhythmias
Cardiac fibroblast inflammasome and atrial myopathy
['FUNDING_R01'] · BAYLOR COLLEGE OF MEDICINE · NIH-11044205
This study is looking at how inflammation might cause atrial fibrillation, a heart rhythm problem, by exploring a specific pathway in heart cells, and it's aimed at finding new ways to help people with this condition feel better and improve their heart health.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | BAYLOR COLLEGE OF MEDICINE (nih funded) |
| Locations | 1 site (HOUSTON, UNITED STATES) |
| Trial ID | NIH-11044205 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of inflammation in the development of atrial fibrillation (AF), a common heart rhythm disorder. It specifically examines how the NLRP3 inflammasome pathway in cardiac fibroblasts contributes to atrial myopathy, which can lead to AF. By studying the molecular mechanisms involved, the researchers aim to identify potential therapeutic strategies that could reduce inflammation and improve heart function. Patients with persistent AF will be compared to those with normal heart rhythms to uncover critical differences in cardiac function.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with persistent atrial fibrillation or those experiencing symptoms related to atrial myopathy.
Not a fit: Patients without a history of atrial fibrillation or those with other unrelated cardiac conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent or reduce the severity of atrial fibrillation and improve heart health.
How similar studies have performed: Previous research has shown that targeting inflammatory pathways can be beneficial in other cardiovascular conditions, suggesting potential for success in this area as well.
Where this research is happening
HOUSTON, UNITED STATES
- BAYLOR COLLEGE OF MEDICINE — HOUSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LI, NA — BAYLOR COLLEGE OF MEDICINE
- Study coordinator: LI, NA
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Amplified in Breast Cancer 1, Amplified in Breast Cancer 1 Protein