Investigating how inflammation affects depression and testing a new treatment
A translational study of neuroinflammatory depression: Understanding mechanism and evaluation of a novel pharmacologic intervention
This study is looking at different types of depression and how inflammation in the brain might affect them, and it will test if a new anti-inflammatory medicine called celecoxib can help improve symptoms for people who show signs of this inflammation.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-11037728 on NIH RePORTER |
What this research studies
This research focuses on understanding the different subtypes of major depressive disorder (MDD) and how neuroinflammation may play a role in these subtypes. By using advanced imaging techniques like positron emission tomography (PET), researchers aim to identify specific biological markers associated with neuroinflammation in patients with MDD. The study will also evaluate the effectiveness of a novel anti-inflammatory medication, celecoxib, to see if it can improve depression symptoms in patients who exhibit these neuroinflammatory markers. This approach aims to personalize treatment options for individuals suffering from depression.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with major depressive disorder, particularly those who may have a neuroinflammatory component to their condition.
Not a fit: Patients with depression not associated with neuroinflammation or those who do not meet the criteria for major depressive disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, targeted treatments for patients with major depressive disorder, improving their overall mental health outcomes.
How similar studies have performed: Previous research has shown promising results in targeting neuroinflammation in depression, suggesting that this approach may lead to significant advancements in treatment.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Parsey, Ramin V. — State University New York Stony Brook
- Study coordinator: Parsey, Ramin V.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.