Investigating how inflammation affects depression and testing a new treatment
A translational study of neuroinflammatory depression: Understanding mechanism and evaluation of a novel pharmacologic intervention
This study is looking at different types of depression and how inflammation in the brain might affect them, and it will test a new medication to see if it helps improve symptoms for people with these specific types of depression.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project ID | NIH-10800717 on NIH RePORTER |
What this research studies
This research focuses on understanding the different subtypes of major depressive disorder (MDD) and how neuroinflammation may play a role in these variations. By using advanced imaging techniques like positron emission tomography (PET), the study aims to identify specific biological markers associated with neuroinflammation in patients with MDD. The researchers will also evaluate the effectiveness of a novel anti-inflammatory medication, celecoxib, to see if it can improve depression symptoms in individuals with this subtype. This approach seeks to personalize treatment options based on individual patient profiles, potentially leading to better outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with major depressive disorder, particularly those who may have a neuroinflammatory subtype.
Not a fit: Patients with depression that does not involve neuroinflammation or those who do not meet the criteria for major depressive disorder may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective, targeted treatments for patients suffering from major depressive disorder.
How similar studies have performed: Other research has shown promise in targeting neuroinflammation for treating depression, suggesting that this approach may be viable.
Where this research is happening
Stony Brook, United States
- State University New York Stony Brook — Stony Brook, United States (Active)
Researchers
- Principal investigator: Parsey, Ramin V. — State University New York Stony Brook
- Study coordinator: Parsey, Ramin V.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.