Investigating how inflammation affects depression and cognitive function in people with HIV.
The Role of Inflammation in CNS Mechanisms of Anhedonia and Psychomotor Slowing in Depressed PWH as Determined using a Next Generation TNF Antagonist
['FUNDING_R01'] · EMORY UNIVERSITY · NIH-10692700
This study is looking at how inflammation might affect depression in people with HIV, and it aims to see if a new treatment can help improve mood and thinking by reducing inflammation.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | EMORY UNIVERSITY (nih funded) |
| Locations | 1 site (ATLANTA, UNITED STATES) |
| Trial ID | NIH-10692700 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the connection between inflammation and depression in individuals living with HIV. It examines how elevated inflammatory markers, such as C-reactive protein and tumor necrosis factor, contribute to symptoms like anhedonia and psychomotor slowing. The study utilizes advanced neuroimaging techniques to explore brain connectivity and its relationship with cognitive function and mood. By targeting inflammation with a next-generation TNF antagonist, the research aims to improve treatment outcomes for depressed individuals with HIV.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are experiencing symptoms of depression and have elevated inflammatory markers.
Not a fit: Patients who do not have HIV or those without depressive symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for depression in people with HIV, enhancing their overall quality of life.
How similar studies have performed: Previous research has shown promising results in targeting inflammation to alleviate depressive symptoms, suggesting potential success for this approach.
Where this research is happening
ATLANTA, UNITED STATES
- EMORY UNIVERSITY — ATLANTA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FELGER, JENNIFER C — EMORY UNIVERSITY
- Study coordinator: FELGER, JENNIFER C
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome, Alzheimer's Disease