Investigating how inflammation affects cancer growth in the brain and spinal cord.
Official title: Inflammatory Signaling in the Leptomeninges
Funded at Sloan-Kettering Inst Can Research · NIH-11108295 · Data updated 2026-11-12
This study is looking at how inflammation around the brain and spinal cord might help cancer spread in people with leptomeningeal metastasis, and it hopes to find new ways to improve treatment for this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sloan-Kettering Inst Can Research NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | March 11, 2025 |
| Project end | February 28, 2030 |
| Funding year | 2025 |
| Award (this year) | $730,398 |
| NIH project number | 1R01CA300788-01 |
| Project ID | NIH-11108295 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with leptomeningeal metastasis from various cancers.
✕Less likely to help
Patients without cancer or those with cancers that do not metastasize to the leptomeningeal space may not benefit from this research.
What this research studies
This research focuses on leptomeningeal metastasis, a serious condition where cancer spreads into the fluid-filled spaces around the brain and spinal cord. It aims to understand how inflammation in these areas may actually help cancer cells grow. By analyzing clinical samples and using mouse models, the researchers will explore the signaling mechanisms involved, particularly the role of a protein called CXCL1. This could lead to new insights into how to better treat or manage this type of cancer.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for patients with leptomeningeal metastasis, potentially enhancing survival and quality of life.
How similar studies have gone: Previous research has shown promising results in understanding cancer signaling in other contexts, suggesting potential for success in this area as well.
Where this research is happening
-
Sloan-Kettering Inst Can Research
New York, United States Active
Researchers
- Principal investigator: Boire, Adrienne a. — Sloan-Kettering Inst Can Research
- Study coordinator: Boire, Adrienne a.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.