Investigating how inflammation affects brain function after carbon monoxide exposure
Inflammatory changes and glymphatic dysfunction in carbon monoxide neuropathology
This study is looking at how inflammation and a specific brain cleaning system might affect brain injuries from carbon monoxide poisoning, using animal models to understand the role of certain particles in brain damage, and then connecting those findings to real-life cases of people who have been affected by CO poisoning.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Maryland Baltimore NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-11052641 on NIH RePORTER |
What this research studies
This research explores the impact of inflammation and glymphatic dysfunction on brain injuries caused by carbon monoxide (CO). The study uses animal models to assess how astrocyte-derived microparticles contribute to neurological damage and inflammation. Researchers will utilize advanced imaging techniques to evaluate glymphatic function and its relationship to brain health. Additionally, the project aims to correlate findings from animal models with clinical data from patients who have experienced CO poisoning.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have suffered from carbon monoxide poisoning and exhibit neurological symptoms.
Not a fit: Patients who have not been exposed to carbon monoxide or do not exhibit any neurological deficits may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for brain injuries caused by carbon monoxide exposure.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammation in brain injuries, suggesting that this approach may yield valuable insights.
Where this research is happening
Baltimore, United States
- University of Maryland Baltimore — Baltimore, United States (Active)
Researchers
- Principal investigator: Thom, Stephen Raymond — University of Maryland Baltimore
- Study coordinator: Thom, Stephen Raymond
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.