Investigating how inflammation affects blood vessel cells and their functions
Metabolic and epigenetic reprogramming in the inflamed endothelium
This study is looking at how inflammation affects the cells that line our blood vessels and how these changes might lead to problems with blood flow and immune responses, which could help us understand and improve treatments for vascular diseases.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Oklahoma Medical Research Foundation NIH-funded |
| Lab location | 1 site (Oklahoma City, United States) |
| Project ID | NIH-11018563 on NIH RePORTER |
What this research studies
This research focuses on endothelial cells, which line blood vessels and play a crucial role in inflammation and various diseases. It aims to understand how inflammation alters the metabolism of these cells, particularly through increased glycolysis, and how these changes can lead to lasting modifications in cell function via epigenetic mechanisms. By examining the relationship between metabolic changes and epigenetic modifications, the research seeks to uncover how these processes may contribute to endothelial dysfunction and potentially influence immune responses. Patients may benefit from insights gained into the underlying mechanisms of vascular diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from conditions associated with endothelial dysfunction, such as cardiovascular diseases or inflammatory disorders.
Not a fit: Patients with non-inflammatory conditions or those without endothelial dysfunction may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating diseases related to endothelial dysfunction and inflammation.
How similar studies have performed: Other research has shown promising results in understanding metabolic and epigenetic changes in various cell types, suggesting that this approach may yield valuable insights.
Where this research is happening
Oklahoma City, United States
- Oklahoma Medical Research Foundation — Oklahoma City, United States (Active)
Researchers
- Principal investigator: Cleuren, Audrey — Oklahoma Medical Research Foundation
- Study coordinator: Cleuren, Audrey
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.