Investigating how inflammation affects blood stem cells with DNMT3A mutations as we age
Inflammatory Signaling in DNMT3A-Mutated Human Hematopoietic Stem Cells
This study is looking at how inflammation affects certain blood stem cells with a specific gene mutation as we get older, and it aims to help us understand how these changes might lead to blood cancers, so we can promote healthier aging for everyone.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Jackson Laboratory NIH-funded |
| Lab location | 1 site (Bar Harbor, United States) |
| Project ID | NIH-11072363 on NIH RePORTER |
What this research studies
This research explores the relationship between inflammation and hematopoietic stem cells (HSCs) that have mutations in the DNMT3A gene, particularly as people age. The team will study how these mutated stem cells expand in number and how inflammation contributes to this process. By analyzing bone marrow samples and using advanced single-cell technologies, the researchers aim to understand the mechanisms behind clonal hematopoiesis, which can lead to blood cancers. The ultimate goal is to promote healthier aging of the blood system through a better understanding of these biological processes.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults who have been diagnosed with clonal hematopoiesis or have a known DNMT3A mutation.
Not a fit: Patients who are younger and do not have any mutations in their hematopoietic stem cells are unlikely to benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing blood cancers in older adults by targeting the mechanisms of clonal expansion in mutated stem cells.
How similar studies have performed: Previous research has shown promising results in understanding the role of inflammation in stem cell biology, suggesting that this approach could yield valuable insights.
Where this research is happening
Bar Harbor, United States
- Jackson Laboratory — Bar Harbor, United States (Active)
Researchers
- Principal investigator: Trowbridge, Jennifer Jean — Jackson Laboratory
- Study coordinator: Trowbridge, Jennifer Jean
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.