Investigating how inflammation affects blood pressure responses during exercise in patients with peripheral artery disease.
Official title: Neuroinflammation as a mediator of the exaggerated Piezo2 and Exercise Pressor Reflex in Peripheral Artery Disease
Funded at University of Minnesota · NIH-10995706 · Data updated 2026-11-12
This study is looking at how inflammation in the muscles of people with peripheral artery disease (PAD) causes their blood pressure to rise too much when they exercise, and it hopes to find ways to make exercising safer for them by understanding a specific receptor involved in this process.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project start | March 5, 2025 |
| Project end | March 4, 2030 |
| Funding year | 2024 |
| Award (this year) | $40,431 |
| NIH project number | 1F31HL175929-01 |
| Project ID | NIH-10995706 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with peripheral artery disease who experience heightened blood pressure responses during exercise.
✕Less likely to help
Patients without peripheral artery disease or those who do not experience exercise-induced blood pressure elevation may not benefit from this research.
What this research studies
This research focuses on understanding how inflammation in the muscles of patients with peripheral artery disease (PAD) leads to an exaggerated increase in blood pressure during exercise. The study examines the role of a specific receptor, Piezo2, which may be responsible for this heightened response. By using animal models and analyzing inflammatory markers, the research aims to uncover the mechanisms behind this phenomenon. The ultimate goal is to develop therapies that can help normalize blood pressure responses during physical activity, making exercise safer for PAD patients.
Why it matters
Potential benefit: If successful, this research could lead to safer exercise recommendations and improved treatment options for patients with peripheral artery disease.
How similar studies have gone: Previous research has shown that targeting inflammatory pathways can improve outcomes in cardiovascular conditions, suggesting potential success for this approach.
Where this research is happening
-
University of Minnesota
Minneapolis, United States Active
Researchers
- Principal investigator: Oribamise, Eunice — University of Minnesota
- Study coordinator: Oribamise, Eunice
Related research
Other NIH-funded projects on the same topics.
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Low-dose colchicine to reduce vascular risk in people with peripheral artery disease
This project tests whether taking a low-dose anti-inflammatory drug (colchicine) daily can lower heart and limb-related risks for adults with peripheral artery disease.
-
Gamified home walking program to help seniors with peripheral artery disease improve walking and quality of life
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Fatty clues in leg arteries: how fat burning in mitochondria affects PAD and muscle health
This project looks at how fat metabolism in leg muscles relates to weakness and tissue damage in people with peripheral artery disease and aims to find new ways to help them.
-
Enhancing muscle energy to help leg function in PAD
A study to boost how muscle mitochondria work in people with peripheral artery disease to improve walking and leg function.
-
Low-dose colchicine for people with peripheral artery disease to reduce heart and limb risks
A large international study will test whether a low daily dose of colchicine can lower heart and limb complications for people with peripheral artery disease.
-
Low-dose colchicine for reducing vascular risk in people with PAD
A large international study will test whether a daily low dose of colchicine can lower heart and limb-related risks for people with peripheral artery disease.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.