Investigating how inflammation affects blood cell production in the bone marrow
Official title: 3D Human Bone Marrow Microphysiological System Used to Investigate HSPC Mobilization via Inflammation-Derived ExtracellularVesicles
Funded at University of California at Davis · NIH-11066228 · Data updated 2026-11-12
This study is looking at how inflammation affects the movement of important blood cells from the bone marrow, which could help us understand better ways to treat infections and cancer.
Quick facts
| Grant type | Fellowship grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California at Davis NIH-funded |
| Lab location | 1 site (Davis, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $42,058 |
| NIH project number | 1F31AI189814-01 |
| Project ID | NIH-11066228 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with conditions that involve inflammation, such as infections or certain cancers.
✕Less likely to help
Patients with stable, non-inflammatory conditions or those not requiring blood cell mobilization may not benefit from this research.
What this research studies
This research focuses on understanding how inflammation influences the mobilization of hematopoietic stem/progenitor cells (HSPCs) and neutrophils from the bone marrow. Using a specialized 3D bone marrow microphysiological system, the study aims to explore the interactions between various cell types in the bone marrow and how they respond to inflammatory signals. By examining these mechanisms, the research seeks to uncover the processes that regulate blood cell production during conditions like infections and cancer, which could lead to improved treatments.
Why it matters
Potential benefit: If successful, this research could enhance our understanding of blood cell mobilization, potentially leading to better therapies for patients with infections or cancer.
How similar studies have gone: Previous research has shown promising results in understanding blood cell mobilization mechanisms, indicating that this approach has potential for success.
Where this research is happening
-
University of California at Davis
Davis, United States Active
Researchers
- Principal investigator: Zarate-Sanchez, Evelyn — University of California at Davis
- Study coordinator: Zarate-Sanchez, Evelyn
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.