Investigating how inflammasome activity affects heart health in patients with kidney disease
Inflammasome Activity as a Potential Contributor to Uremic Cardiomyopathy
This study is looking at how inflammation affects both the heart and kidneys in people with chronic kidney disease and heart failure, and it aims to see if blocking certain inflammatory substances can help improve heart health for those patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11137217 on NIH RePORTER |
What this research studies
This research explores the connection between chronic kidney disease and heart failure, focusing on how inflammasome activity contributes to inflammation in the heart and kidneys. It examines the roles of specific inflammatory cytokines, such as interleukin-1β and interleukin-18, in heart function and aims to determine if blocking these cytokines can improve heart health in affected patients. The study involves both animal models and potential future clinical applications for patients with heart failure or coronary artery disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with chronic kidney disease who are at risk for heart failure or have existing heart conditions.
Not a fit: Patients without chronic kidney disease or those who do not have heart-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and reduce hospitalizations for patients with chronic kidney disease and heart failure.
How similar studies have performed: Previous research has shown that targeting inflammatory pathways can improve heart function in patients with heart failure, indicating a promising approach.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Buckley, Leo Francis — Brigham and Women's Hospital
- Study coordinator: Buckley, Leo Francis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.