Investigating how inflammasome activity affects heart health in patients with kidney disease
Inflammasome Activity as a Potential Contributor to Uremic Cardiomyopathy
This study is looking at how kidney disease can affect heart health by focusing on inflammation, and it's for people with chronic kidney disease who might benefit from new treatments aimed at improving their heart function.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10894749 on NIH RePORTER |
What this research studies
This research explores the connection between chronic kidney disease and heart failure, focusing on the role of the inflammasome in driving inflammation in both the kidneys and the heart. The study aims to understand how specific inflammatory cytokines, such as interleukin-1β and interleukin-18, contribute to heart dysfunction. By examining these mechanisms, the research seeks to identify potential new treatments that could improve heart function in patients with kidney disease. Patients may be involved in trials that test the effectiveness of blocking these inflammatory pathways to enhance heart health.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults with chronic kidney disease who are at risk for heart failure.
Not a fit: Patients without chronic kidney disease or those with advanced heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart function and reduce heart failure hospitalizations in patients with chronic kidney disease.
How similar studies have performed: Previous research has shown that targeting inflammatory pathways can improve heart function in patients with related conditions, indicating a promising approach.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Buckley, Leo Francis — Brigham and Women's Hospital
- Study coordinator: Buckley, Leo Francis
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.