Investigating how infections may influence glioma development and outcomes
Discovering Infection-mediated Pathways of Glioma Etiology and Prognosis by Leveraging Multiplex Serology and Immunogenomics
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10911153
This study is looking at how infections might affect the development and outcomes of gliomas, a type of brain tumor, by comparing the immune responses of glioma patients with healthy individuals, and it could help us understand how these infections influence the disease and its treatment.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10911153 on ClinicalTrials.gov |
What this research studies
This research aims to understand the role of infections in the development and prognosis of gliomas, a type of malignant brain tumor. By measuring antibody responses to various infections in a large group of glioma patients and healthy controls, the study seeks to identify potential causal pathogens and their impact on glioma risk and survival. Additionally, the research will analyze genetic variations that may affect immune responses to these infections. This comprehensive approach could provide insights into how infections might influence glioma progression and treatment outcomes.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with glioma, particularly those with varying stages of the disease.
Not a fit: Patients with glioma who are not willing to participate in serological testing or genetic analysis may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating gliomas by targeting infection-related pathways.
How similar studies have performed: Previous studies have suggested a link between infections and glioma, but this research employs novel methodologies that have not been extensively tested in this context.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: FRANCIS, STEPHEN STARKO — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: FRANCIS, STEPHEN STARKO
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.