Investigating how infections may influence glioma development and outcomes
Official title: Discovering Infection-mediated Pathways of Glioma Etiology and Prognosis by Leveraging Multiplex Serology and Immunogenomics
Funded at University of California, San Francisco · NIH-10911153 · Data updated 2026-11-12
This study is looking at how infections might affect the development and outcomes of gliomas, a type of brain tumor, by comparing the immune responses of glioma patients with healthy individuals, and it could help us understand how these infections influence the disease and its treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | September 1, 2022 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $630,449 |
| NIH project number | 5R01CA266676-03 |
| Project ID | NIH-10911153 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with glioma, particularly those with varying stages of the disease.
✕Less likely to help
Patients with glioma who are not willing to participate in serological testing or genetic analysis may not benefit from this research.
What this research studies
This research aims to understand the role of infections in the development and prognosis of gliomas, a type of malignant brain tumor. By measuring antibody responses to various infections in a large group of glioma patients and healthy controls, the study seeks to identify potential causal pathogens and their impact on glioma risk and survival. Additionally, the research will analyze genetic variations that may affect immune responses to these infections. This comprehensive approach could provide insights into how infections might influence glioma progression and treatment outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing and treating gliomas by targeting infection-related pathways.
How similar studies have gone: Previous studies have suggested a link between infections and glioma, but this research employs novel methodologies that have not been extensively tested in this context.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Francis, Stephen Starko — University of California, San Francisco
- Study coordinator: Francis, Stephen Starko
Related research
Other NIH-funded projects on the same topics.
-
DNA methylation-based blood biomarkers to predict prognosis and treatment response in glioma patients
A patient-facing summary: researchers will use blood-based DNA methylation markers to help predict how glioma patients might fare and respond to treatments.
-
Blood DNA methylation test to predict glioma outcomes and treatment response
This project uses patterns in blood DNA to help predict how people with glioma will do and how they might respond to treatments.
-
Infections and immune genes linked to adult glioma risk and outlook
Measuring past infections and immune-gene differences in adults to learn how they relate to glioma risk and survival.
-
Colorectal cancer prognosis through a broad, collaborative study
A large, multi-center study follows people newly diagnosed with colorectal cancer to find biomarkers and patterns that predict outcomes and guide future care.
-
Next‑gen oncolytic virus therapy for glioblastoma targeting AKT and ERK
A new cancer therapy using an engineered oncolytic virus to fight glioblastoma by blocking AKT/ERK signals and boosting the body’s immune response, with potential to reduce seizures and improve quality of life.
-
Bone marrow immune cells and glioma progression in teens and young adults
A study in adolescents and young adults with brain tumors looks at how immune cells from bone marrow may influence the progression from low-grade to high-grade gliomas.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.