Investigating how infections can trigger autoimmune responses that affect blood clotting
Thromboinflammatory consequences of infection-induced autoimmunity
This study is looking at how COVID-19 might trigger the body to produce certain antibodies that could lead to blood clotting problems in people with autoimmune diseases, and it’s for anyone interested in understanding how these antibodies behave after recovering from COVID-19.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10876917 on NIH RePORTER |
What this research studies
This research explores the relationship between COVID-19 and autoimmune diseases, particularly focusing on how infections can lead to the production of autoantibodies that may cause blood clotting issues. The study aims to understand the mechanisms behind these autoantibodies and their potential role as therapeutic targets. By analyzing patient serum samples, researchers will investigate the persistence and effects of these antibodies in individuals recovering from COVID-19. This work is being conducted at the University of Michigan, where a strong mentorship environment supports the research efforts.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have recovered from COVID-19 and are experiencing symptoms related to autoimmune diseases or blood clotting issues.
Not a fit: Patients who have not had COVID-19 or do not exhibit any autoimmune symptoms may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from blood clotting disorders related to autoimmune responses triggered by infections.
How similar studies have performed: Other research has shown promising results in understanding the links between infections and autoimmune responses, suggesting that this approach could yield valuable insights.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Zuo, Yu — University of Michigan at Ann Arbor
- Study coordinator: Zuo, Yu
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.