Investigating how infections and antibiotic resistance affect children's health after hospital discharge in Kenya.
The role of enteric pathogens and antimicrobial resistance in driving clinical and nutritional deterioration, and azithromycin's potential effect, among children discharged from hospital in Kenya
This study is looking at how to keep young children healthy after they leave the hospital in Kenya by giving them a short course of antibiotics to see if it helps prevent them from getting sick again or needing to go back to the hospital.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-10809682 on NIH RePORTER |
What this research studies
This research focuses on understanding the health risks faced by children under five years old who have recently been discharged from hospitals in Kenya. It examines the role of enteric pathogens and antibiotic resistance in causing health deterioration during this vulnerable period. By administering a 5-day course of azithromycin at discharge, the study aims to assess its impact on reducing mortality and re-hospitalization rates over the following six months. The research will analyze fecal samples to identify pathogens and resistance genes, linking this data to health outcomes and growth metrics.
Who could benefit from this research
Good fit: Ideal candidates for this research are children under five years old who have recently been discharged from hospitals in resource-limited settings in Kenya.
Not a fit: Patients who are not recently discharged from hospitals or those outside the age range of under five years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved health interventions that significantly reduce mortality and morbidity in young children after hospital discharge.
How similar studies have performed: Previous clinical trials have shown promising results with azithromycin in reducing mortality in similar populations, indicating potential for success in this approach.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Pavlinac, Patricia — University of Washington
- Study coordinator: Pavlinac, Patricia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.