Investigating how infant blood DNA changes relate to asthma and allergies.
Infant blood epigenome and risks of IgE sensitization, obesity, and asthma: MARC-35/43 cohorts
['FUNDING_R01'] · HARVARD SCHOOL OF PUBLIC HEALTH · NIH-10684901
This study is looking at how changes in babies' DNA might affect their chances of developing allergies, obesity, and asthma, and it's for families with infants, especially those who have had bronchiolitis or are healthy, to help find ways to prevent these conditions as they grow up.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | HARVARD SCHOOL OF PUBLIC HEALTH (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10684901 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how changes in DNA methylation in infants' blood can influence the development of allergies, obesity, and asthma. By studying two large groups of infants—one with a history of bronchiolitis and another with healthy infants—the researchers aim to identify early risk factors for these conditions. Participants will undergo various assessments, including blood tests and follow-up interviews, to track their health outcomes over several years. The goal is to find modifiable factors that could help prevent asthma and related issues in childhood.
Who could benefit from this research
Good fit: Ideal candidates for this research include infants, particularly those hospitalized for bronchiolitis or those who are healthy.
Not a fit: Patients who are older than 21 years or those without a history of asthma or allergies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to early interventions that reduce the risk of asthma and allergies in children.
How similar studies have performed: Previous research has shown promise in identifying early risk factors for asthma, making this approach both relevant and potentially impactful.
Where this research is happening
BOSTON, UNITED STATES
- HARVARD SCHOOL OF PUBLIC HEALTH — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LIANG, LIMING — HARVARD SCHOOL OF PUBLIC HEALTH
- Study coordinator: LIANG, LIMING
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.