Investigating how improved blood sugar control affects brain glucose transport in type 2 diabetes.
Official title: Reversibility of brain glucose kinetics in type 2 diabetic subjects
Funded at Yale University · NIH-11124882 · Data updated 2026-11-12
This study is looking at how high blood sugar from type 2 diabetes might affect how sugar gets to your brain and if keeping your blood sugar in check can help improve brain function, so it's for people with diabetes who want to learn more about how managing their condition could benefit their thinking and memory.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | July 15, 2023 |
| Project end | May 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $194,724 |
| NIH project number | 5K23DK132517-03 |
| Project ID | NIH-11124882 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults with poorly controlled type 2 diabetes who are experiencing cognitive difficulties.
✕Less likely to help
Patients with well-controlled diabetes or those without cognitive impairments may not benefit from this research.
What this research studies
This research focuses on understanding how chronic high blood sugar levels in type 2 diabetes can impair glucose transport to the brain, potentially leading to cognitive decline. The study aims to determine if better management of blood sugar levels can reverse these effects and restore normal brain glucose metabolism. Using advanced imaging techniques, researchers will assess changes in brain function and glucose transport in patients with poorly controlled diabetes. The findings could provide insights into the relationship between diabetes management and brain health.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies that protect brain function in individuals with type 2 diabetes.
How similar studies have gone: Previous studies have indicated that improving blood sugar control can have positive effects on brain health, suggesting potential success for this approach.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Sanchez Rangel, Elizabeth — Yale University
- Study coordinator: Sanchez Rangel, Elizabeth
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.