Investigating how immunity to dengue virus affects Zika virus infections in primates
Dengue-Zika: Correlates of Cross-Protection in Non-Human Primates
This study is looking at how having immunity to dengue might affect how sick you get from Zika, using monkeys to help understand the immune responses, which could lead to better vaccines for both viruses.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Puerto Rico Med Sciences NIH-funded |
| Lab location | 1 site (San Juan, United States) |
| Project ID | NIH-10757891 on NIH RePORTER |
What this research studies
This research explores the interactions between dengue and Zika viruses, particularly how prior immunity to one virus may influence the severity of infection from the other. Using non-human primates that closely mimic the human immune system, the study aims to identify immune responses that could provide protection against severe disease. The researchers will analyze how immune responses to dengue may enhance or mitigate Zika infections, focusing on the cellular immune response. This work is crucial for understanding the implications of these viruses in endemic regions and could inform future vaccine development.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research would include individuals with a history of dengue virus infection, particularly those living in endemic regions.
Not a fit: Patients who have not been exposed to either dengue or Zika viruses may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for preventing severe infections from dengue and Zika viruses.
How similar studies have performed: Previous studies have shown that immune responses to related viruses can influence disease severity, suggesting that this research could build on established findings.
Where this research is happening
San Juan, United States
- University of Puerto Rico Med Sciences — San Juan, United States (Active)
Researchers
- Principal investigator: Sariol, Carlos a — University of Puerto Rico Med Sciences
- Study coordinator: Sariol, Carlos a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.