Investigating how immune system genes affect Alzheimer's disease
Molecular genetic analyses of transcriptional dysregulation in Alzheimers disease
['FUNDING_R01'] · INDIANA UNIVERSITY INDIANAPOLIS · NIH-11054583
This study is looking at how certain genes, like PU.1, affect the immune cells in the brain that play a role in Alzheimer's disease, hoping to find new ways to help people understand their risk and improve treatments.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | INDIANA UNIVERSITY INDIANAPOLIS (nih funded) |
| Locations | 1 site (INDIANAPOLIS, UNITED STATES) |
| Trial ID | NIH-11054583 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the role of the immune system, particularly microglia, in Alzheimer's disease (AD). It aims to explore how specific genetic risk factors, like the PU.1 gene, influence microglial function and their interaction with amyloid beta, a key protein involved in AD pathology. By utilizing advanced technologies such as single-cell RNA sequencing and human-induced pluripotent stem cells, the research seeks to uncover new insights into the disease mechanisms and identify potential therapeutic targets. Patients may benefit from a better understanding of how their genetic makeup influences their risk for AD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those who have been diagnosed with early-stage Alzheimer's.
Not a fit: Patients with other forms of dementia unrelated to Alzheimer's disease may not receive benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for Alzheimer's disease by targeting specific genetic factors.
How similar studies have performed: Previous research has shown promising results in understanding the immune system's role in Alzheimer's disease, indicating that this approach could lead to significant advancements.
Where this research is happening
INDIANAPOLIS, UNITED STATES
- INDIANA UNIVERSITY INDIANAPOLIS — INDIANAPOLIS, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: KIM, JUNGSU — INDIANA UNIVERSITY INDIANAPOLIS
- Study coordinator: KIM, JUNGSU
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer disease dementia, Alzheimer syndrome