Investigating how immune signaling affects migraine pain
Meningeal Nociceptor-Immune Signaling in Migraine
This study is looking at how certain pain-sensing nerves in the brain's protective layers interact with the immune system to better understand what triggers migraines, with the hope of finding new ways to help people who suffer from them.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10582390 on NIH RePORTER |
What this research studies
This research explores the relationship between meningeal nociceptors, which are pain-sensing nerve endings in the protective membranes of the brain, and the immune system in the context of migraine. By examining how these nociceptors interact with immune cells, the study aims to uncover new mechanisms that may contribute to migraine attacks. The researchers will utilize advanced techniques to analyze these interactions and their potential role in migraine pain, which could lead to novel therapeutic approaches for patients suffering from migraines.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who experience recurrent migraine attacks and are seeking new treatment options.
Not a fit: Patients who do not suffer from migraines or have other unrelated headache disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or prevent migraine attacks.
How similar studies have performed: While the specific approach of examining nociceptor-immune interactions in migraine is relatively novel, there is a growing body of evidence supporting the role of neurogenic inflammation in headache disorders.
Where this research is happening
Boston, United States
- Beth Israel Deaconess Medical Center — Boston, United States (Active)
Researchers
- Principal investigator: Levy, Dan — Beth Israel Deaconess Medical Center
- Study coordinator: Levy, Dan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.