Investigating how immune responses in the body and brain affect cognitive decline in aging and Alzheimer's disease

Who could benefit from this research

What this research studies

This research explores the impact of immune responses from both the brain and the peripheral body on cognitive decline associated with aging and Alzheimer's disease. It aims to understand how changes in immune cells outside the brain, known as peripheral myeloid cells, contribute to cognitive issues, alongside the role of brain-specific immune cells called microglia. By using innovative techniques, the study will compare the effects of these two immune systems on cognitive health in aging and Alzheimer's models. This could lead to new insights into how to prevent or treat cognitive decline in older adults.

Why it matters

Where this research is happening

• Stanford University
  Stanford, United States Active

Researchers

• Principal investigator: Andreasson, Katrin I. — Stanford University
• Study coordinator: Andreasson, Katrin I.

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About this research

1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.