Investigating how immune responses in the body and brain affect cognitive decline in aging and Alzheimer's disease
The role of peripheral versus brain myeloid immunity in the cognitive decline of aging and Alzheimer's disease
['FUNDING_OTHER'] · STANFORD UNIVERSITY · NIH-10524957
This study is looking at how immune cells in the brain and body affect memory and thinking problems that come with aging and Alzheimer's disease, and it’s for older adults who want to understand more about what might help keep their minds sharp.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | STANFORD UNIVERSITY (nih funded) |
| Locations | 1 site (STANFORD, UNITED STATES) |
| Trial ID | NIH-10524957 on ClinicalTrials.gov |
What this research studies
This research explores the impact of immune responses from both the brain and the peripheral body on cognitive decline associated with aging and Alzheimer's disease. It aims to understand how changes in immune cells outside the brain, known as peripheral myeloid cells, contribute to cognitive issues, alongside the role of brain-specific immune cells called microglia. By using innovative techniques, the study will compare the effects of these two immune systems on cognitive health in aging and Alzheimer's models. This could lead to new insights into how to prevent or treat cognitive decline in older adults.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults experiencing cognitive decline or those at risk for Alzheimer's disease.
Not a fit: Patients with cognitive decline due to non-aging related factors may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating cognitive decline in aging and Alzheimer's disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of immune responses in cognitive decline, but this specific approach is relatively novel.
Where this research is happening
STANFORD, UNITED STATES
- STANFORD UNIVERSITY — STANFORD, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: ANDREASSON, KATRIN I. — STANFORD UNIVERSITY
- Study coordinator: ANDREASSON, KATRIN I.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Alzheimer's Disease, Alzheimer disease, Alzheimer syndrome, Alzheimer's disease dementia, Alzheimers disease