Investigating how immune responses and antibiotic use affect sepsis in children
PediatRic sEpsiS induCed MODS: Relationship of Immune-phenotypes and antiBiotic Exposures (PRESCRIBE) study
This study is looking at how kids with sepsis and multi-organ dysfunction respond to antibiotics, so we can find the best way to give them the right medicine based on their unique immune systems and gut bacteria, helping them get better faster.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-11094091 on NIH RePORTER |
What this research studies
This research focuses on understanding the relationship between immune responses, antibiotic pharmacokinetics, and the microbiome in children suffering from sepsis and multi-organ dysfunction syndrome (MODS). By examining how these factors interact, the study aims to optimize antibiotic dosing and improve treatment outcomes for pediatric patients. The research will involve analyzing blood samples and other clinical data to identify variations in antibiotic effectiveness based on individual immune responses and microbiome composition. This approach seeks to ensure that children receive the most effective antibiotic treatment tailored to their specific needs.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are diagnosed with sepsis and experiencing multi-organ dysfunction.
Not a fit: Patients who are not diagnosed with sepsis or are older than 11 years may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized antibiotic treatments for children with sepsis, potentially reducing morbidity and mortality.
How similar studies have performed: Previous research has shown promising results in understanding the immune response and antibiotic effectiveness in pediatric populations, indicating that this approach has potential for success.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Downes, Kevin James — Children's Hosp of Philadelphia
- Study coordinator: Downes, Kevin James
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.