Investigating how immune responses affect neurological issues in veterans after COVID-19
Immune-mediated pathogenic mechanisms of Neuro-PASC in Veterans
['FUNDING_OTHER'] · PORTLAND VA MEDICAL CENTER · NIH-11075830
This study is looking at how the immune system might cause brain and mood issues in veterans who have had long-lasting effects from COVID-19, and it aims to find clues in their blood that could help explain why some people feel worse than others.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | PORTLAND VA MEDICAL CENTER (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-11075830 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the immune-mediated mechanisms that lead to neurological problems in veterans who have experienced post-acute sequelae of SARS-CoV-2 infection (neuro-PASC). The team will explore how specific inflammatory factors, signaling pathways, and genetic predispositions contribute to symptoms such as cognitive difficulties, depression, and anxiety. By analyzing blood samples and patient histories, they aim to identify biomarkers that correlate with the severity of these neuropsychiatric symptoms. This comprehensive approach seeks to uncover the underlying biological processes that persist after COVID-19 infection.
Who could benefit from this research
Good fit: Ideal candidates for this research are veterans who have experienced COVID-19 and are currently facing neurological symptoms such as cognitive impairment, anxiety, or depression.
Not a fit: Patients who have not had COVID-19 or do not exhibit neurological symptoms related to the infection may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to targeted therapies that alleviate neurological symptoms in veterans suffering from long-term effects of COVID-19.
How similar studies have performed: Previous research has indicated a link between inflammatory responses and neuropsychiatric symptoms in COVID-19 patients, suggesting that this approach has potential for success.
Where this research is happening
PORTLAND, UNITED STATES
- PORTLAND VA MEDICAL CENTER — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: LOFTIS, JENNIFER M — PORTLAND VA MEDICAL CENTER
- Study coordinator: LOFTIS, JENNIFER M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: adverse sequelae of coronavirus disease, adverse sequelae of coronavirus disease 2019