Investigating how immune responses affect Alzheimer's disease progression
Maladaptive antiviral pathways in Alzheimer's disease
This study is looking at how certain immune responses in the brain might make Alzheimer's disease worse, and it's hoping to find new ways to help improve memory and learning for people with this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11076744 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of maladaptive immune responses, particularly involving microglia, in the progression of Alzheimer's disease (AD). It aims to uncover how these immune pathways, specifically the cGAS-STING signaling pathway, contribute to tau pathology and cognitive decline in AD. By studying mouse models of tauopathy, the research seeks to identify potential therapeutic strategies that could mitigate the harmful effects of these immune responses on memory and learning. Patients may benefit from insights that could lead to new treatments targeting these immune mechanisms.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or those at risk due to genetic factors associated with immune response.
Not a fit: Patients with early-stage Alzheimer's disease or those without genetic predispositions linked to immune responses may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies that improve cognitive function in Alzheimer's disease patients.
How similar studies have performed: Previous research has shown promising results in understanding the role of immune responses in neurodegenerative diseases, suggesting that this approach may yield significant insights.
Where this research is happening
New York, United States
- Weill Medical Coll of Cornell Univ — New York, United States (Active)
Researchers
- Principal investigator: Gan, Li — Weill Medical Coll of Cornell Univ
- Study coordinator: Gan, Li
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.