Investigating how immune cells recognize cancer cells to develop new antibody therapies.
Understanding and Mimicking TCR Recognition with Therapeutic Monoclonal Antibodies.
['FUNDING_OTHER'] · SLOAN-KETTERING INST CAN RESEARCH · NIH-10854838
This study is looking at how certain immune cells can spot and target cancer cells in people with acute leukemia, with the goal of creating new and safer treatments that help the body fight cancer more effectively.
Quick facts
| Phase | ['FUNDING_OTHER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SLOAN-KETTERING INST CAN RESEARCH (nih funded) |
| Locations | 1 site (NEW YORK, UNITED STATES) |
| Trial ID | NIH-10854838 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding how T cell receptors (TCR) identify cancer cells, particularly in acute leukemia, to create innovative monoclonal antibody therapies. The approach involves leveraging decades of prior work to develop safe and selective immunotherapies that can distinguish cancer cells from healthy ones. By exploring various forms of antibodies and their interactions with cancer-specific antigens, the research aims to enhance the effectiveness of treatments and potentially lead to breakthroughs in cancer therapy.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients diagnosed with acute leukemia who may benefit from advanced immunotherapy options.
Not a fit: Patients with non-cancerous conditions or those not diagnosed with acute leukemia may not receive any benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of highly targeted therapies that improve treatment outcomes for patients with acute leukemia.
How similar studies have performed: Previous research has shown success in developing targeted immunotherapies, indicating a promising potential for this innovative approach.
Where this research is happening
NEW YORK, UNITED STATES
- SLOAN-KETTERING INST CAN RESEARCH — NEW YORK, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHEINBERG, DAVID A — SLOAN-KETTERING INST CAN RESEARCH
- Study coordinator: SCHEINBERG, DAVID A
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.