Investigating how immune cells present antigens to T cells in Alzheimer's disease
Defining MHC class I restricted antigen presentation to CD8 T cells in experimental AD and Tauopathy
This study is looking at how certain immune cells, called CD8 T cells, affect Alzheimer's disease and other brain conditions, hoping to find new ways to help treat these diseases.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-11090369 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of specific immune cells, particularly CD8 T cells, in Alzheimer's disease (AD) and other neurodegenerative conditions. It aims to explore how these immune cells interact with the brain and contribute to the disease's progression. By using advanced mouse models, the researchers will analyze the mechanisms of antigen presentation and the effects of immune cell infiltration in the brain. This study could provide insights into the immune response in AD and potentially identify new therapeutic targets.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with Alzheimer's disease or related neurodegenerative conditions.
Not a fit: Patients with other forms of dementia not related to Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for treating or preventing Alzheimer's disease by targeting immune responses.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in neurodegenerative diseases, indicating that this approach could yield valuable insights.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Johnson, Aaron J — Mayo Clinic Rochester
- Study coordinator: Johnson, Aaron J
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.