Investigating how immune cells interact with skin stem cells
Official title: Exploring immune-mediated stem cell heterogeneity within and across niches
Funded at Rockefeller University · NIH-10949298 · Data updated 2026-11-12
This study is looking at how immune cells and skin stem cells work together to create different types of skin cells, which could help us find better treatments for skin conditions.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Rockefeller University NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $115,106 |
| NIH project number | 1K99AR084573-01 |
| Project ID | NIH-10949298 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with skin conditions or disorders that may involve stem cell dysfunction or immune system interactions.
✕Less likely to help
Patients with non-skin-related conditions or those not experiencing any skin issues may not receive benefits from this research.
What this research studies
This research explores the complex interactions between immune cells and skin epithelial stem cells to understand how these interactions contribute to the diversity and functionality of skin cells. By examining the heterogeneity of stem cells within different skin compartments, the study aims to uncover the mechanisms that drive these variations. The approach includes advanced techniques like single-cell RNA sequencing to analyze the behavior of these cells in response to environmental stressors. Patients may benefit from insights that could lead to improved treatments for skin-related conditions.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for enhancing skin health and treating skin disorders.
How similar studies have gone: Other research has shown promising results in understanding immune and stem cell interactions, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Rockefeller University
New York, United States Active
Researchers
- Principal investigator: Parigi, Sara Martina — Rockefeller University
- Study coordinator: Parigi, Sara Martina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.