Investigating how immune cells interact with pathogens in cystic fibrosis lung inflammation
Macrophage Pathogen Interactions in Regional Cystic Fibrosis Lung Inflammation
This study is looking at how immune cells in the lungs of people with cystic fibrosis respond to infections, which could help us find better ways to treat lung inflammation in these patients.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dartmouth-Hitchcock Clinic NIH-funded |
| Lab location | 1 site (Lebanon, United States) |
| Project ID | NIH-10844500 on NIH RePORTER |
What this research studies
This research focuses on understanding the interactions between immune cells, specifically macrophages, and pathogens in the lungs of patients with cystic fibrosis. The project aims to explore how macrophages from different regions of the lung respond to infections, particularly looking at their metabolism and inflammatory responses. By using lung macrophages obtained from human subjects, the research will investigate how these immune cells behave differently based on their location in the lung and how this affects inflammation caused by infections. The findings could lead to improved treatment strategies for lung inflammation in cystic fibrosis patients.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with cystic fibrosis who are experiencing lung inflammation.
Not a fit: Patients without cystic fibrosis or those not experiencing significant lung inflammation may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective therapies for managing lung inflammation in cystic fibrosis patients.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in lung diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Lebanon, United States
- Dartmouth-Hitchcock Clinic — Lebanon, United States (Active)
Researchers
- Principal investigator: Ashare, Alix — Dartmouth-Hitchcock Clinic
- Study coordinator: Ashare, Alix
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.