Investigating how immune cells interact with fibroblasts in pancreatic cancer
Targeting the fibroblast-immune cell crosstalk to relieve immune suppression in the pancreatic cancer microenvironment
This study is looking at how certain cells in the pancreas work together to hide pancreatic cancer from the immune system, and it's hoping to find new ways to help treatments work better for patients with this type of cancer.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10904995 on NIH RePORTER |
What this research studies
This research focuses on understanding the interactions between immune cells and fibroblasts in the pancreatic cancer environment, which is known to suppress immune responses. By using genetically engineered mouse models, the study aims to explore how these interactions contribute to immune suppression early in cancer development. The researchers will analyze immune cell behavior and gene expression patterns to identify potential targets for new therapies that could enhance the effectiveness of immunotherapy in pancreatic cancer patients.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with pancreatic cancer or those at high risk for developing the disease.
Not a fit: Patients with other types of cancer or those without pancreatic cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that improve immune responses against pancreatic cancer.
How similar studies have performed: Previous research has shown promise in targeting immune suppression in other cancers, suggesting that this approach may also be effective in pancreatic cancer.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Pasca Di Magliano, Marina — University of Michigan at Ann Arbor
- Study coordinator: Pasca Di Magliano, Marina
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.