Investigating how immune cells interact in asthma-related airway inflammation
Official title: Epithelial Immune Cell Interactions in Persistent T2 Inflammation
Funded at University of Washington · NIH-11289484 · Data updated 2026-11-12
This study is looking at how certain immune cells affect the airways in children with asthma, especially those who have ongoing inflammation, to find out what makes their symptoms worse, particularly during colds or viruses, with the hope of discovering better ways to help them breathe easier.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project start | April 1, 2025 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $247,508 |
| NIH project number | 5U19AI175089-03 |
| Project ID | NIH-11289484 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are children aged 0-11 years who have asthma and experience persistent airway inflammation.
✕Less likely to help
Patients with asthma who do not have persistent type-2 inflammation or those outside the age range may not benefit from this research.
What this research studies
This research focuses on understanding the interactions between immune cells and airway epithelial cells in children with asthma, particularly those experiencing persistent type-2 inflammation. The researchers will use advanced models to study how mast cells and eosinophils infiltrate the airway epithelium and contribute to airway dysfunction. By examining these cellular interactions, the study aims to uncover mechanisms that exacerbate asthma symptoms, especially during respiratory viral infections. The findings could lead to new therapeutic strategies for managing asthma in affected children.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments for children with asthma, particularly those who do not respond well to current therapies.
How similar studies have gone: Previous research has shown promising results in understanding immune cell interactions in asthma, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Washington
Seattle, United States Active
Researchers
- Principal investigator: Hallstrand, Teal S — University of Washington
- Study coordinator: Hallstrand, Teal S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.