Investigating how immune cells contribute to lung injury during COVID-19 in hamsters
Digital pathology for defining myeloid cell-mediated lung injury during acute SARS CoV-2 Infection in hamsters
This study is looking at how certain immune cells in hamsters might cause lung problems during COVID-19, with the goal of finding better ways to treat the disease.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Tufts University Boston NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10700811 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of immune cells, specifically macrophages and neutrophils, in causing lung injury during COVID-19 using a hamster model. The researchers aim to use advanced digital pathology techniques to analyze immune cell behavior and their impact on disease progression. By establishing standardized methods for assessing these immune responses, the study seeks to improve the understanding of COVID-19 pathology and identify potential therapeutic targets. The findings could help in developing better treatments for COVID-19 by targeting myeloid cells.
Who could benefit from this research
Good fit: Ideal candidates for benefiting from this research would be individuals affected by COVID-19, particularly those experiencing severe symptoms.
Not a fit: Patients who are not affected by COVID-19 or those with mild cases may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapeutic strategies for COVID-19 by targeting specific immune responses.
How similar studies have performed: Other research has shown success in using animal models to understand COVID-19 pathology, making this approach both relevant and promising.
Where this research is happening
Boston, United States
- Tufts University Boston — Boston, United States (Active)
Researchers
- Principal investigator: Martinot, Amanda — Tufts University Boston
- Study coordinator: Martinot, Amanda
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.