Investigating how immune cells contribute to blood vessel inflammation in HIV patients
The proinflammatory functions of granzymes and their impact on endothelial inflammation/injury
This study is looking at how certain immune cells in people with HIV might be causing inflammation and damage to blood vessels, which could lead to heart problems, and it hopes to find new ways to improve heart health for those living with HIV.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Georgetown University NIH-funded |
| Lab location | 1 site (Washington, United States) |
| Project ID | NIH-11142641 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of immune cells, specifically CD8 T cells, in causing inflammation and injury to blood vessels in individuals living with HIV. It aims to explore how these immune cells produce substances called granzymes that may worsen cardiovascular health. By examining the behavior of these cells and their impact on blood vessel function, the study seeks to uncover new insights that could lead to better treatments for heart-related issues in HIV patients. The research will involve analyzing immune cell activity and its effects on vascular health over time.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals living with HIV who are undergoing antiretroviral therapy and may be experiencing cardiovascular issues.
Not a fit: Patients who are not living with HIV or those who do not have cardiovascular concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for reducing cardiovascular risks in people living with HIV.
How similar studies have performed: Previous research has indicated that immune activation plays a significant role in cardiovascular health among HIV patients, suggesting that this approach could yield valuable insights.
Where this research is happening
Washington, United States
- Georgetown University — Washington, United States (Active)
Researchers
- Principal investigator: Catalfamo, Marta L. — Georgetown University
- Study coordinator: Catalfamo, Marta L.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.