Investigating how immune cells contribute to aging and inflammation in tissues
Core B - Biological Analysis
This study is looking at how certain immune cells contribute to inflammation and aging in different parts of the body, and it's for anyone interested in understanding how these changes might affect health as we get older.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project ID | NIH-10901927 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of immune cells in producing factors that contribute to inflammation and aging in various tissues. By using advanced techniques such as single-cell analysis and spatial multi-omics sequencing, the team aims to create detailed maps of senescent cells in tissues like the thymus, bone marrow, and adipose tissue. This work will help identify new biomarkers and understand how these cells affect the surrounding tissue environment, which is crucial for addressing age-related diseases.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults or individuals with conditions related to aging and inflammation.
Not a fit: Patients who are younger and do not have age-related conditions or inflammatory diseases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights and treatments for age-related diseases by targeting the mechanisms of immune senescence.
How similar studies have performed: Other research has shown promise in understanding immune senescence and its effects on aging, indicating that this approach could yield valuable insights.
Where this research is happening
New Haven, United States
- Yale University — New Haven, United States (Active)
Researchers
- Principal investigator: Fan, Rong — Yale University
- Study coordinator: Fan, Rong
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.