Investigating how immune cells communicate during tissue damage in diabetes
Macrophages, Cell-Cell Communication, Ischemic Injury in Diabetes and the RAGE/DIAPH1 Signaling Axis
This study is looking at how a type of immune cell called macrophages reacts to damage in the heart and muscles of people with diabetes, focusing on a specific receptor that might help us find better ways to improve healing and reduce complications from this condition.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10642704 on NIH RePORTER |
What this research studies
This research focuses on understanding how macrophages, a type of immune cell, respond to ischemic injury in diabetic patients. It examines the role of a specific receptor, RAGE, and its signaling pathways in the recruitment and activation of these cells in heart and muscle tissues. By studying animal models, the research aims to uncover the mechanisms that lead to impaired tissue repair in diabetes, which could help identify new therapeutic targets. Patients may benefit from insights gained about how to improve healing and reduce complications related to ischemia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with diabetes who are experiencing cardiovascular issues or peripheral arterial disease.
Not a fit: Patients without diabetes or those not experiencing ischemic injuries may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance tissue repair and reduce complications in diabetic patients suffering from ischemic injuries.
How similar studies have performed: Other research has shown promising results in understanding immune cell behavior in ischemic conditions, suggesting that this approach may lead to significant advancements.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Schmidt, Ann Marie — New York University School of Medicine
- Study coordinator: Schmidt, Ann Marie
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.