Investigating how immune cells change during pregnancy
Official title: Gestationally driven trafficking of decidual lymphocytes assessed by serial intravascular staining
Funded at University of Wisconsin-Madison · NIH-10873209 · Data updated 2026-11-12
This study is looking at how certain immune cells behave in the tissue that supports pregnancy, using a special method to see how they move and change during pregnancy in macaques, which could help us understand issues like preeclampsia and preterm labor.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Wisconsin-Madison NIH-funded |
| Lab location | 1 site (Madison, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $194,375 |
| NIH project number | 5R21AI175753-02 |
| Project ID | NIH-10873209 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pregnant individuals or those planning to become pregnant, particularly those at risk for complications like preeclampsia.
✕Less likely to help
Patients who are not pregnant or those with unrelated health conditions may not benefit from this research.
What this research studies
This research focuses on understanding the behavior of immune cells in the decidua, a tissue that plays a crucial role during pregnancy. By using a novel technique called serial intravascular staining, the study aims to track how these immune cells, particularly lymphocytes, move and change in number throughout pregnancy in a macaque model. This approach will help uncover the dynamics of these cells and their potential impact on pregnancy outcomes, such as preeclampsia and preterm labor.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic and therapeutic strategies for pregnancy-related complications.
How similar studies have gone: While the specific approach of using serial intravascular staining in this context is novel, similar studies have shown promise in understanding immune dynamics in other conditions.
Where this research is happening
-
University of Wisconsin-Madison
Madison, United States Active
Researchers
- Principal investigator: Stanic-Kostic, Aleksandar — University of Wisconsin-Madison
- Study coordinator: Stanic-Kostic, Aleksandar
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.