Investigating how immune cells affect Multiple Sclerosis through new tissue models
From single molecule to microfluidic 3D tissue platforms: novel multiscale tools to investigate hyper-stimulated immune cells in the circulation
This study is looking at how overactive immune cells in the blood of people with Multiple Sclerosis interact with the brain's protective barrier, which could help us find new ways to treat the condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Michigan State University NIH-funded |
| Lab location | 1 site (East Lansing, United States) |
| Project ID | NIH-11141851 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of hyper-stimulated immune cells in the circulation of patients with Multiple Sclerosis (MS). By utilizing innovative microfluidic 3D tissue platforms, the team aims to explore how these immune cells interact with the blood-brain barrier and contribute to the disease's progression. The approach combines basic science with clinical insights to uncover the mechanisms behind the immune response in MS, potentially leading to new therapeutic strategies. Patients may be involved in studies that analyze their blood samples and responses to various stimuli.
Who could benefit from this research
Good fit: Ideal candidates for participation are individuals diagnosed with Multiple Sclerosis who are willing to provide blood samples for analysis.
Not a fit: Patients without a diagnosis of Multiple Sclerosis or those who are not experiencing symptoms related to the disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that better manage or even prevent the progression of Multiple Sclerosis.
How similar studies have performed: Previous research has shown promising results in understanding immune responses in MS, indicating that this approach could yield valuable insights.
Where this research is happening
East Lansing, United States
- Michigan State University — East Lansing, United States (Active)
Researchers
- Principal investigator: Spence, Dana M — Michigan State University
- Study coordinator: Spence, Dana M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.