Investigating how immune cells affect cognitive aging and dementia.
Role of Peripheral Immune Cells in Cognitive Aging: The Framingham Offspring Study
This study is looking at how certain immune cells in your blood might affect memory and thinking as we age, especially for people with Alzheimer's and other types of dementia, to help find new ways to prevent or treat these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston University Medical Campus NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10810793 on NIH RePORTER |
What this research studies
This research explores the connection between peripheral immune cells and cognitive aging, particularly in relation to Alzheimer's disease and other dementias. By studying the Framingham Offspring cohort, which includes detailed cognitive assessments and brain imaging, the research aims to uncover how immune system activity influences cognitive decline. The approach involves analyzing blood samples to identify immune cell characteristics that may predict cognitive outcomes. This could lead to new biomarkers and therapies for preventing or treating dementia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals from the Framingham Offspring cohort who are experiencing cognitive aging or are at risk for Alzheimer's disease.
Not a fit: Patients who are not part of the Framingham Offspring cohort or those without cognitive aging concerns may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cognitive decline and improving treatment options for dementia.
How similar studies have performed: Previous research has shown promising results in understanding the role of immune cells in cognitive decline, suggesting that this approach may yield valuable insights.
Where this research is happening
Boston, United States
- Boston University Medical Campus — Boston, United States (Active)
Researchers
- Principal investigator: Murabito, Joanne M — Boston University Medical Campus
- Study coordinator: Murabito, Joanne M
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.