Investigating how immune cells affect abdominal aortic aneurysms
Spatiotemporal checkpoints of macrophages in aortic aneurysms- Renewal
This study is looking at how certain immune cells called macrophages affect the growth of abdominal aortic aneurysms, with the hope of finding new ways to prevent these aneurysms from getting worse or bursting.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11127495 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of macrophages, a type of immune cell, in the progression of abdominal aortic aneurysms (AAA). By examining how these cells interact with their environment and contribute to the weakening of the aortic wall, the study aims to identify potential therapeutic targets. The researchers will utilize advanced techniques such as single-cell RNA sequencing to analyze the behavior of macrophages in both human and mouse models of AAA. The goal is to develop new strategies to inhibit the inflammatory processes that lead to aneurysm growth and rupture.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with abdominal aortic aneurysms or those at high risk for developing them.
Not a fit: Patients without abdominal aortic aneurysms or those with other unrelated vascular conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that prevent the progression of abdominal aortic aneurysms, potentially saving lives.
How similar studies have performed: Previous research has shown promising results in targeting macrophage activity in vascular diseases, suggesting that this approach may be effective.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Ramkhelawon, Bhama — New York University School of Medicine
- Study coordinator: Ramkhelawon, Bhama
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.