Investigating how immune activation affects the brain's blood barrier after traumatic brain injury.
Assessing the effects of peripheral immune activation on the NVU following TBI using a vascularized and perfused human blood/BBB model
This study is looking at how the immune system affects brain health after a traumatic brain injury by creating a 3D model of the blood-brain barrier using human cells, and it aims to find new ways to improve treatments for people recovering from such injuries.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10925418 on NIH RePORTER |
What this research studies
This research focuses on understanding the impact of immune responses on the neurovascular unit (NVU) following traumatic brain injury (TBI). It aims to create a 3D model that mimics the human blood-brain barrier (BBB) using cells derived from human stem cells, along with patient blood components. By examining how these blood components influence the function of the NVU, the study seeks to uncover mechanisms that could lead to better treatments for TBI. Patients' plasma proteins and immune cells will be analyzed to understand their effects on brain health post-injury.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have experienced a traumatic brain injury and are willing to contribute blood samples for analysis.
Not a fit: Patients with non-traumatic brain injuries or those who do not have access to the required medical facilities may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved therapeutic strategies for patients suffering from traumatic brain injuries.
How similar studies have performed: Previous research has shown promise in using similar 3D models to study brain conditions, indicating that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Agalliu, Dritan — Columbia University Health Sciences
- Study coordinator: Agalliu, Dritan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.