Investigating how immune activation affects brain blood vessels after traumatic brain injury.
Assessing the effects of peripheral immune activation on the NVU following TBI using a vascularized and perfused human blood/BBB model
This study is looking at how a traumatic brain injury might affect the blood vessels in your brain and how this could lead to memory problems or Alzheimer's disease later on, with the hope of finding new ways to help prevent these issues for people who have had a TBI.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10940105 on NIH RePORTER |
What this research studies
This research explores the impact of traumatic brain injury (TBI) on the brain's blood vessels and how immune responses may contribute to cognitive decline and Alzheimer's disease. By using a human blood-brain barrier model, the study aims to understand the molecular mechanisms that lead to increased risk of Alzheimer's and related dementias following TBI. The approach involves assessing changes in blood vessel integrity and immune activation in response to injury, which could reveal potential therapeutic targets for preventing cognitive impairment. Patients may benefit from insights gained into the relationship between TBI and Alzheimer's disease progression.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals who have experienced a traumatic brain injury and are at risk for cognitive impairment or Alzheimer's disease.
Not a fit: Patients who have not experienced a traumatic brain injury or do not have risk factors for Alzheimer's disease may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing cognitive decline in individuals who have suffered a traumatic brain injury.
How similar studies have performed: Previous research has shown promising results in understanding the relationship between immune responses and cognitive decline following brain injuries, suggesting that this approach could yield valuable insights.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Agalliu, Dritan — Columbia University Health Sciences
- Study coordinator: Agalliu, Dritan
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.