Investigating how IL22 signaling affects epilepsy development
IL22 Signaling in Epilepsy
['FUNDING_R01'] · ALBANY MEDICAL COLLEGE · NIH-10760319
This study is looking at how a healthy brain can develop epilepsy after injuries or genetic changes, focusing on how inflammation and certain brain cells interact, which could help us find better ways to prevent or treat epilepsy.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | ALBANY MEDICAL COLLEGE (nih funded) |
| Locations | 1 site (ALBANY, UNITED STATES) |
| Trial ID | NIH-10760319 on ClinicalTrials.gov |
What this research studies
This research focuses on understanding the process of epileptogenesis, which transforms a normal brain into an epileptic one, often triggered by genetic mutations or neurological injuries. The study examines the role of brain inflammation and immune cells, particularly how they interact with astrocytes and neurons in response to these injuries. By exploring the up-regulation of IL22Rα1 in astrocytes during this process, the research aims to uncover mechanisms that contribute to the excessive activation of astrocytes in epileptic brains. This could lead to new insights into preventing or treating epilepsy.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with epilepsy or those at risk of developing epilepsy due to genetic or neurological factors.
Not a fit: Patients with epilepsy caused by non-inflammatory factors or those who do not have a neurological condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies for preventing or treating epilepsy.
How similar studies have performed: Other research has shown promising results in understanding the role of immune signaling in epilepsy, suggesting that this approach may yield valuable insights.
Where this research is happening
ALBANY, UNITED STATES
- ALBANY MEDICAL COLLEGE — ALBANY, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: HUANG, YUNFEI — ALBANY MEDICAL COLLEGE
- Study coordinator: HUANG, YUNFEI
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.