Investigating how IL17RC signaling affects gut bacteria and inflammation in heart disease
Official title: IL17RC signaling as a regulator of host- microbiota interactions and aortic neuroinflammation in atherosclerosis
Funded at Cedars-Sinai Medical Center · NIH-11045738 · Data updated 2026-11-12
This study is looking at how a specific signaling pathway in the immune system affects the relationship between gut bacteria and heart health, especially in people with atherosclerosis, to find new ways to help prevent or treat heart disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Cedars-Sinai Medical Center NIH-funded |
| Lab location | 1 site (Los Angeles, United States) |
| Project start | April 1, 2024 |
| Project end | February 29, 2028 |
| Funding year | 2025 |
| Award (this year) | $631,679 |
| NIH project number | 5R01HL173975-02 |
| Project ID | NIH-11045738 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals at risk for atherosclerosis or those with existing cardiovascular diseases.
✕Less likely to help
Patients without cardiovascular disease or those not affected by gut microbiota changes may not benefit from this research.
What this research studies
This research explores the role of IL17RC signaling in regulating the interactions between gut microbiota and the immune system, particularly in the context of atherosclerosis, a major cardiovascular disease. By using a specialized mouse model, the study aims to uncover how changes in gut bacteria can influence inflammation in the aorta and contribute to the progression of heart disease. The researchers will analyze the effects of IL17RC on intestinal health and its potential impact on cardiovascular conditions, providing insights into new therapeutic targets.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve heart health by targeting gut microbiota and inflammation.
How similar studies have gone: Previous research has shown promising results in understanding the role of microbiota in cardiovascular diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Cedars-Sinai Medical Center
Los Angeles, United States Active
Researchers
- Principal investigator: Koltsova, Ekaterina — Cedars-Sinai Medical Center
- Study coordinator: Koltsova, Ekaterina
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.