Investigating how IL-37 affects immune system regulation in human T cells
The role of IL-37 in human regulatory T cells
This study is looking at how a special protein called IL-37 helps control certain immune cells that keep our immune system balanced, and it could lead to new treatments for autoimmune diseases and other immune-related issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10880622 on NIH RePORTER |
What this research studies
This research explores the role of the anti-inflammatory cytokine IL-37 in regulating human regulatory T cells, which are crucial for maintaining immune system balance. By analyzing human T cells and using advanced techniques, the study aims to understand how IL-37 influences Treg cell function and stability. The researchers will utilize both primary human Treg cells and T cell lines to investigate the molecular mechanisms behind IL-37's effects. The findings could provide insights into new therapeutic strategies for autoimmune diseases and other conditions related to immune dysfunction.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with autoimmune conditions or those experiencing immune system dysregulation.
Not a fit: Patients with acute infections or those not experiencing immune-related issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that enhance immune tolerance and improve outcomes for patients with autoimmune diseases.
How similar studies have performed: Previous research has shown promising results in understanding the role of cytokines in immune regulation, suggesting that this approach could yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Fujita, Mayumi — University of Colorado Denver
- Study coordinator: Fujita, Mayumi
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.