Investigating how IL-33 and ST2 control inflammation and fibrosis
Official title: On- and Off-Axis Control of Fibrosis by IL-33 and ST2
Funded at Baltimore VA Medical Center · NIH-10951496 · Data updated 2026-11-12
This study is looking at how a protein called IL-33 and its receptor ST2 can help manage inflammation and scarring in different diseases, with the hope of finding new ways to treat these conditions.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Baltimore VA Medical Center NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project start | October 1, 2023 |
| Project end | September 30, 2027 |
| Funding year | 2025 |
| NIH project number | 5I01BX006173-02 |
| Project ID | NIH-10951496 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with inflammatory or fibrotic conditions, such as asthma, allergies, or other related diseases.
✕Less likely to help
Patients with non-inflammatory conditions or those not affected by fibrosis may not benefit from this research.
What this research studies
This research focuses on the roles of Interleukin-33 (IL-33) and its receptor ST2 in managing various inflammatory and fibrotic diseases. It examines both the mature form of IL-33 and its full-length precursor to understand their distinct effects on inflammation and fibrosis. The study aims to uncover how these molecules interact and influence immune responses, potentially leading to new therapeutic strategies. By exploring both 'on-axis' and 'off-axis' pathways, the research seeks to clarify the mechanisms behind these conditions and identify new targets for treatment.
Why it matters
Potential benefit: If successful, this research could lead to new treatments for patients suffering from inflammatory and fibrotic diseases.
How similar studies have gone: Previous research has shown promising results in understanding the roles of IL-33 and ST2 in inflammation, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Baltimore VA Medical Center
Baltimore, United States Active
Researchers
- Principal investigator: Luzina, Irina G. — Baltimore VA Medical Center
- Study coordinator: Luzina, Irina G.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.