Investigating how IL-33 affects lung injury after stem cell transplants in children
Official title: IL-33 induced-lL-9 producing type 2 innate lymphoid cells in the regulation of acute lung injury after hematopoietic stem cell transplantation (HSCT) in pediatric patients
Funded at Medical University of South Carolina · NIH-10756116 · Data updated 2026-11-12
This study is looking at how certain immune cells and a protein called IL-33 might cause lung problems in kids who have had a stem cell transplant, with the goal of finding better ways to help them breathe easier and stay healthy after their treatment.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Medical University of South Carolina NIH-funded |
| Lab location | 1 site (Charleston, United States) |
| Project start | January 1, 2022 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $551,368 |
| NIH project number | 5R01HL158096-03 |
| Project ID | NIH-10756116 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are pediatric patients who are undergoing or have undergone hematopoietic stem cell transplantation.
✕Less likely to help
Patients who are not undergoing HSCT or have conditions unrelated to graft-versus-host disease may not benefit from this research.
What this research studies
This research focuses on understanding the role of IL-33 and type 2 innate lymphoid cells in causing lung injury following hematopoietic stem cell transplantation (HSCT) in pediatric patients. The study aims to identify mechanisms behind graft-versus-host disease (GVHD) and its impact on lung function, particularly in the context of acute lung injury. By exploring biomarkers and cellular interactions, the research seeks to develop better therapeutic strategies to mitigate these complications. Patients may be monitored for specific immune responses and lung health during and after their transplant.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that reduce lung injury and enhance recovery for children undergoing stem cell transplants.
How similar studies have gone: Previous research has shown promising results in understanding immune responses related to GVHD, indicating potential for success in this area.
Where this research is happening
-
Medical University of South Carolina
Charleston, United States Active
Researchers
- Principal investigator: Paczesny, Sophie — Medical University of South Carolina
- Study coordinator: Paczesny, Sophie
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.