Investigating how IL-27 protects during congenital infections
IL-27 is a protective cytokine during congenital infection
This study is looking at how a substance called IL-27 helps manage the immune system during pregnancy, especially in protecting both moms and their babies from infections, to find ways to improve health outcomes for both.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10780182 on NIH RePORTER |
What this research studies
This research explores the role of the cytokine IL-27 in regulating immune responses during pregnancy, particularly at the maternal-fetal interface. It aims to understand how IL-27 can act as both a pro-inflammatory and anti-inflammatory agent, depending on the context, and how it influences viral infections. By studying the mechanisms of IL-27 signaling, the research seeks to uncover its protective effects against congenital infections, which could improve outcomes for both mothers and their developing fetuses.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant individuals who are at risk of congenital infections.
Not a fit: Patients who are not pregnant or those who do not have a risk of congenital infections may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic strategies to enhance maternal and fetal health during infections.
How similar studies have performed: Previous research has shown promising results regarding the role of cytokines in pregnancy, suggesting that this approach could yield significant insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Jurado, Kellie Ann — University of Pennsylvania
- Study coordinator: Jurado, Kellie Ann
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.