Investigating how IL-27 affects immune responses in newborns with sepsis
Understanding IL-27 as a negative regulator of protective immunity during neonatal sepsis
This study is looking at how a substance called interleukin-27 (IL-27) affects the immune system of newborns, especially those who might get serious infections, to find ways to help them fight off these infections better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | West Virginia University NIH-funded |
| Lab location | 1 site (Morgantown, United States) |
| Project ID | NIH-11098581 on NIH RePORTER |
What this research studies
This research focuses on understanding the role of interleukin-27 (IL-27) in the immune response of newborns, particularly those at risk of sepsis. By studying how IL-27 levels change during bacterial infections, the researchers aim to identify potential targets for improving immune responses in vulnerable infants. The approach includes using mouse models to observe the effects of IL-27 on survival and recovery from infections, which may lead to new treatment strategies for neonatal sepsis.
Who could benefit from this research
Good fit: Ideal candidates for this research are newborns, especially pre-term or low birthweight infants, who are at high risk for infections.
Not a fit: Patients who are older children or adults may not benefit from this research as it specifically targets neonatal immune responses.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments that enhance the immune response in newborns, potentially reducing mortality from sepsis.
How similar studies have performed: Previous studies have shown promising results in understanding immune responses in neonatal populations, suggesting that targeting IL-27 could be a viable approach.
Where this research is happening
Morgantown, United States
- West Virginia University — Morgantown, United States (Active)
Researchers
- Principal investigator: Robinson, Cory Michael — West Virginia University
- Study coordinator: Robinson, Cory Michael
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.