Investigating how IL-22 affects immune responses and tissue repair in gum disease
IL-22, Immune Plasticity, and Autotherapy in the Periodontium
This study is looking at how a substance called Interleukin-22 (IL-22) affects gum disease by helping the immune system fight infections and heal tissues, with the goal of finding new ways to improve oral health for patients.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10814194 on NIH RePORTER |
What this research studies
This research explores the role of Interleukin-22 (IL-22) in periodontal disease, focusing on its dual effects on immune responses and tissue regeneration. By understanding how IL-22 influences the immune system's ability to maintain tissue health and repair, the study aims to develop autotherapies that enhance the body's natural healing processes. Patients may benefit from insights into how their immune system can be optimized to combat gum disease and promote better oral health.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals suffering from periodontal disease or those at risk of developing it.
Not a fit: Patients without periodontal disease or those with other unrelated oral health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that improve healing and immune function in patients with gum disease.
How similar studies have performed: Previous research has shown promising results in using immune modulation for tissue repair, suggesting potential success for this approach.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Hajishengallis, Georgios — University of Pennsylvania
- Study coordinator: Hajishengallis, Georgios
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.