Investigating how IL-17A contributes to psoriatic arthritis
Official title: Cellular and Molecular Mechanisms of IL-17A in the Pathogenesis of Psoriatic Arthritis
Funded at Beth Israel Deaconess Medical Center · NIH-11164302 · Data updated 2026-11-12
This study is looking at how a protein called IL-17A contributes to psoriatic arthritis, which causes joint pain and inflammation, using a special animal model to find new ways to help people with this condition feel better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Beth Israel Deaconess Medical Center NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | May 15, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $664,933 |
| NIH project number | 1R01AR084848-01A1 |
| Project ID | NIH-11164302 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with psoriatic arthritis who may benefit from new treatment options.
✕Less likely to help
Patients with other forms of arthritis or those not diagnosed with psoriatic arthritis may not receive any benefit from this research.
What this research studies
This research focuses on understanding the role of IL-17A in the development of psoriatic arthritis (PsA), a condition that causes painful inflammation in the joints. The researchers have created a novel animal model that mimics the symptoms of PsA, allowing them to study the cellular and molecular mechanisms involved in the disease. By examining how IL-17A signaling affects joint and skin inflammation, the team aims to identify new therapeutic targets that could lead to more effective treatments for patients suffering from PsA.
Why it matters
Potential benefit: If successful, this research could lead to the development of targeted therapies that improve treatment outcomes for patients with psoriatic arthritis.
How similar studies have gone: Previous research has shown promising results in targeting IL-17A for psoriasis treatment, but this approach for psoriatic arthritis is still being explored and is considered novel.
Where this research is happening
-
Beth Israel Deaconess Medical Center
Boston, United States Active
Researchers
- Principal investigator: Adamopoulos, Iannis Elias — Beth Israel Deaconess Medical Center
- Study coordinator: Adamopoulos, Iannis Elias
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.