Investigating how IL-17 receptor A affects bone health in aging
Official title: Role of IL-17 receptor A in aging bone remodeling
Funded at Emory University · NIH-11077366 · Data updated 2026-11-12
This study is looking at how a specific protein called the IL-17 receptor affects bone health as we get older, and it aims to find out if removing this receptor from certain bone cells can help improve bone strength and healing in older adults.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Emory University NIH-funded |
| Lab location | 1 site (Atlanta, United States) |
| Project start | August 1, 2023 |
| Project end | April 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $450,806 |
| NIH project number | 5R01AG083154-03 |
| Project ID | NIH-11077366 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are older adults experiencing bone health issues or fractures.
✕Less likely to help
Patients who are younger or do not have any bone health concerns may not benefit from this research.
What this research studies
This research explores the role of the IL-17 receptor A in the process of bone remodeling as people age. It focuses on how inflammatory signals, particularly from the IL-17 family of cytokines, influence bone health and healing. The study will examine the effects of deleting the IL-17 receptor in specific bone cells (osteoclasts) to see if this can lead to increased bone mass and improved fracture healing. By understanding these mechanisms, the research aims to identify potential therapeutic targets for enhancing bone health in older adults.
Why it matters
Potential benefit: If successful, this research could lead to new treatments that improve bone health and healing in older adults.
How similar studies have gone: Other research has shown promising results in understanding the role of inflammatory cytokines in bone health, suggesting that this approach could yield significant insights.
Where this research is happening
-
Emory University
Atlanta, United States Active
Researchers
- Principal investigator: Drissi, Moulay Hicham — Emory University
- Study coordinator: Drissi, Moulay Hicham
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.